EFFECTIVENESS TEST OF THE COMBINATION OF ETHANOL EXTRACT OF MIANA LEAVES (COLEUS SCUTELLARIOIDES (L.) BENTH) AND PEGAGAN LEAVES (CENTELLA ASIATICA (L.) URB) AS ANTIBACTERIAL AGAINST STREPTOCOCCUS PNEUMONIAE AND KLEBSIELLA PNEUMONIAE CAUSING COUGH

Kasih Karunia, Afica Prisca Pandin, Sesilia R. Pakadang

Abstract


Miana leaves (Coleus scutellarioides L, Benth) and Pegagan Leaves (Centella asiatica L Urban) have been used by the societies as cough suppressants. Cough-causing bacteria include Streptococcus pneumoniae and Klebsiella pneumonia. Our study objective is determine inhibitory power of Miana Leaves Extract and Pegagan Leaves extract combination on the growth of Streptococcus pneumoniae and Klebsiella pneumoniae. The samples have been used in this study were Streptococcus pneumoniae and Klebsiella pneumoniae, and the simplicia as the test materials were Miana Leaves and Pegagan Leaves obtained from Makassar City. Inhibitory zone Streptococus pneumoniae Miana Leaves Extract (MLE) 50mg by 9.33mm, Pegagan Leaves Extract (PLE) 50mg 9.33mm, MLE 50mg: PLE 50mg 16mm, MLE 50mg: PLE 100mg 13.66mm, MLE 100mg: PLE 50mg 13.66mm, while the negative control using Sodium CMC does not have a zone of resistance. The inhibitory power for Klebsiella pneumonia is MLE 50mg 11.33mm, PLE 50mg 11mm, MLE 50mg: PLE 50mg 17.33mm, MLE 50mg: PLE 100mg 12 mm, MLE 100mg: PLE 50mg 13mm, negative controls using Sodium CMC there are no inhibitory zones. The results of the study concluded that the combination of Miana Leaves extract and Pegagan Leaves has a good inhibitory effectiveness compared to its own use.

 Keywords: Miana, Pegagan, Effectiveness, Streptococcus pneumoniae Klebsiella pneumonia

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DOI: https://doi.org/10.32382/uh.v2i1.1173

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