Mutiah Dwi Humairah, Uleng Bahrun, Liong Boy Kurniawan


Diabetes melitus type 2 (DM Type 2) is a disorder characterized by an increase in blood glucose and has become a world health problem due to high rates of morbidity and mortality. Complications of DM occur because glucose levels in the blood are not well controlled, one of which is diabetic nephropathy due to glomerular damage. Renal function monitoring is usually increased in patients with kidney damage, so KIM-1 plays a role in the development of interstitial fibrosis in kidney disease and can be used to indicate early kidney damage as in several studies that have shown the role of KIM-1 as a tubular biomarker in cases of DM. This study aims to analyze the relationship between levels of Kidney Injury Molecule – 1 (KIM-1) with Glomerular Filtration Rate (GFR) in patients with type 2 Diabetes melitus. The data in this study used 60 subjects consisting of 43.33% male and 56.67 % are female. KIM-1 levels were checked using the ELISA method. The results of this study showed that the mean GFR was 103.82 ml/min/1.73m2 and the average KIM-1 level was 1.887 ng/mL. Statistically, it shows that there is a strong correlation in a negative direction between the GFR and KIM-1 variables (r=-0.657 p=<0.001), the higher the GFR value, the lower the KIM-1 value, and vice versa. The conclusion shows that there is a relationship between Kidney Injury Molecule-1 levels and Glomerulus Filtration Rate in type 2 Diabetes melitus patients


Abd El Dayem, S., El Bohy, A. E. M. and El Shehaby, A. (2016) ‘Value of the intrarenal arterial resistivity indices and different renal biomarkers for early identification of diabetic nephropathy in type 1 diabetic patients’, Journal of Pediatric Endocrinology and Metabolism, 29(3), pp. 273–279. doi: 10.1515/jpem-2014-0397.

Balqis, L. F. et al. (2016) ‘Validitas Kidney Injury Molecule-1 Urin Metode Mikro Enzyme-Linked Immunosorbent Assay Sebagai Penanda Dini Gangguan Ginjal Akut pada Sepsis’, Majalah Kedokteran Bandung, 48(1), pp. 19–25. doi: 10.15395/mkb.v48n1.729.

Bhavsar, N. A. et al. (2012) ‘Neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule 1 (KIM-1) as predictors of incident CKD stage 3: The atherosclerosis risk in communities (ARIC) study’, American Journal of Kidney Diseases. Elsevier Inc., 60(2), pp. 233–240. doi: 10.1053/j.ajkd.2012.02.336.

Cai, J. et al. (2019) ‘Kidney injury molecule-1 expression predicts structural damage and outcome in histological acute tubular injury’, Renal Failure. Taylor & Francis, 41(1), pp. 80–87. doi: 10.1080/0886022X.2019.1578234.

Huo, W. et al. (2010) ‘Kidney injury molecule-1 (KIM-1): a novel kidney-specific injury molecule playing potential double-edged functions in kidney injury’, Transplantation Reviews. Elsevier Inc., 24(3), pp. 143–146. doi: 10.1016/j.trre.2010.02.002.

Indriani, E., Amalia, R. and Levita, J. (2021) ‘Peran dan Metode Pengukuran Protein Kidney Injury Molecule-1 (Kim-1) sebagai Biomarker pada Cedera Ginjal Akut’, Jurnal Sains Farmasi & Klinis, 8(2), p. 93. doi: 10.25077/jsfk.8.2.93-106.2021.

Irwansyah, I. and Kasim, I. S. (2020) ‘Deteksi Dini Risiko Diabetes Melitus Pada Staff Pengajar Stikes Megarezky Makassar’, Jurnal Ilmiah Kesehatan Sandi Husada, 11(1), pp. 540–547. doi: 10.35816/jiskh.v10i2.343.

Khan, F. A. et al. (2019) ‘Evaluation of kidney injury molecule-1 as a disease progression biomarker in diabetic nephropathy’, Pakistan Journal of Medical Sciences, 35(4), pp. 992–996. doi: 10.12669/pjms.35.4.154.

Kunaryanti, Andriyani, A. and Wulandari, R. (2018) ‘Hubungan Tingkat Pengetahuan Tentang DM Dengan Perilaku Mengontrol Gula Darah Pada Pasine DM Rawat Jalan RSUD Moewardi Surakarta’, 11(1), pp. 49–56.

MacGregor, M. S. (2017) ‘How common is early chronic kidney disease?: A Background Paper prepared for the UK Consensus Conference on early chronic kidney disease’, Nephrology Dialysis Transplantation, 22(SUPPL.9), pp. 8–18. doi: 10.1093/ndt/gfm444.

Mandrekar, J. N. (2010) ‘Receiver operating characteristic curve in diagnostic test assessment’, Journal of Thoracic Oncology. International Association for the Study of Lung Cancer, 5(9), pp. 1315–1316. doi: 10.1097/JTO.0b013e3181ec173d.

Mochamad Joni Pranata,Hidayatun Nufus, D. P. (2018) ‘Hubungan Gaya Hidup Dengan Kejadian Diabetes Mellitus Pada Lansia’, Journal of Chemical Information and Modeling, 53(9), pp. 1689–1699.

Paper, F. W. (2011) ‘Novel Biomarkers of Diabetic Nephropathy’, Pacific Biomarkers, (10), pp. 12–14.

Rinawati, W. and Aulia, D. (2011) ‘Kidney Injury Molecule-1 ( KIM-1 ) sebagai Penanda Baru Nekrosis Tubular Akut’, Majalah Kedokteran Indonesia, 61(2), pp. 81–85.

Sabbisetti, V. S. et al. (2014) ‘Blood kidney injury molecule-1 is a biomarker of acute and chronic kidney injury and predicts progression to ESRD in type I diabetes’, Journal of the American Society of Nephrology, 25(10), pp. 2177–2186. doi: 10.1681/ASN.2013070758.

Spasojević-Dimitrijeva, B. et al. (2017) ‘Serum neutrophil gelatinase-associated lipocalin and urinary kidney injury molecule-1 as potential biomarkers of subclinical nephrotoxicity after gadolinium-based and iodinated-based contrast media exposure in pediatric patients with normal kidney functio’, Medical Science Monitor, 23, pp. 4299–4305. doi: 10.12659/MSM.903255.

Tangkelangi, M. (2017) ‘Kidney Injury Molecule-1 (Kim-1) as Early Biomarker of Diabetic Nephropathy in Diabetes Mellitus Type 2 Patients Kidney Injury Molecule-1 (Kim-1) Sebagai Biomarker Dini Nefropati Diabetik Pada Pasien Diabetes Melitus Tipe 2’, Jurnal Info Kesehatan, 15(2), pp. 367–379.

Tian, L. et al. (2017) ‘Kidney Injury Molecule-1 is Elevated in Nephropathy and Mediates Macrophage Activation via the Mapk Signalling Pathway’, Cellular Physiology and Biochemistry, 41(2), pp. 769–783. doi: 10.1159/000458737.

Vujičić, B. et al. (2012) ‘Pathophysiology and Complications of Diabetes Mellitus, Chapter 4- Diabetic Nephropathy’, pp. 71–96.

Widhyasih, R. M., Sari, R. N. P. and Mujianto, B. (2021) ‘Korelasi Antara Kadar Hba1c Dengan Laju Filtrasi Glomerulus (LFG) Pada Pasien Diabetes Melitus’, Journal of Indonesian Medical Laboratory and Science, 2(1), pp. 83–95.

Zdziechowska, M. et al. (2020) ‘Serum NGAL, KIM-1, IL-18, L-FABP: new biomarkers in the diagnostics of acute kidney injury (AKI) following invasive cardiology procedures’, International Urology and Nephrology. Springer Netherlands, 52(11), pp. 2135–2143. doi: 10.1007/s11255-020-02530-x.



  • There are currently no refbacks.

Published By : Jurusan Analis Kesehatan Politeknik Kesehatan Makassar

Office : Jl. Wijaya Kusuma Raya No. 52 Banta-Bantaeng, Makassar, South Sulawesi, 90222  View on Google Maps

Email  :

media analis kesehatan indexed by :


Protected By                             


Media Reference Manager



Flag Counter

View My Stats