FORMULASI PATCH ANTIPIRETIK YANG MENGANDUNG EKSTRAK  COCOR BEBEK (Kalanchoe pinnata)

Santi Sinala; Ismail Ibrahim; Sisilia Teresia Rosmala Dewi

doi:10.32382/mf.v17i1.1972

FORMULASI PATCH ANTIPIRETIK YANG MENGANDUNG EKSTRAK COCOR BEBEK (Kalanchoe pinnata)

Santi Sinala, Ismail Ibrahim, Sisilia Teresia Rosmala Dewi

Abstract

Antipyretic Patch Formulation Containing Extract (Kalanchoe Pinnata)

Fever in children requires special treatments coupled with practical use of drugs. Therefore, this research aims to formulate antipyretic patch preparations containing Kalanchoe pinnata plant extracts. The plant was first extracted using the maceration method, meanwhile, the patch formulation was made with 3 different concentrations of Na CMC base. Thereafter, the extract was then added to the base patch. The three formulas were tested for the characteristics, namely organoleptic, weight uniformity, thickness, percentage of water loss, pH, and folding resistance. The results showed that the three formulas have the same organoleptic color, namely green, F1 is not homogeneous, while F2 and F3 are homogeneous. Moreover, the three formulas met the weight uniformity requirements, while in the thickness test, F3 is thicker compared to F2 and F1. F3 has a water content greater than F2 and F1, meanwhile, the three formulas have a pH of 6 and folding resistance > 300 times. Based on the results, Formula 2 (F2) has better physical stability compared to F1 and F3.

Keywords: Kalanchoe pinnata, patch, antipyretic

Demam pada anak membutuhkan penanganan khusus dimana penggunaan obat harus lebih praktis. Penelitian ini akan memformulasi sediaan patch bberbahadan dasar tanaman cocor bebek. Penelitian ini bertujuan untuk memformulasi sediaan patch antipretik yang mengandung ekstrak tanaman cocor bebek. Tanaman cocor bebek terlebih dahulu diekstraksi menggunakan metode maserasi untuk menghasilkan ekstrak. Formulasi patch dibuat dengan 3 konsentrasi basis Na CMC yang berbeda. Ekstrak kemudian ditambahkan ke dalam basis patch. Ketiga formula diuji karakteristiknya meliputi uji organoleptis, keseragaman bobot, uji ketebalan, persentase kehilangan air, uji pH dan uji daya tahan lipat. Hasil pengujian diperoleh dimana ketiga formula memiliki organoleptis warna yang sama yaitu hijau, F1 tidak homogen, sedangkan F2 dan F3 homogen. Pada uji keseragaman bobot, ketiga formula memenuhi syarat keseragaman bobot. Pada uji ketebalan, F3 lebih tebal dibandingkan dari F2 dan F1. F3 memiliki kadar air yang lebih besar dibandingkan dengan F2 dan F1. Pada uji pH, ketiga formula memiliki pH 6 dan memiliki kemampuan bertahan meski telah dilipat >300 kali. Formula 2 (F2) memiliki kestabilan fisik yang lebih baik disbanding dari F1 dan F3.

Kata Kunci : Cocor bebek, patch, antipiretik

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DOI: https://doi.org/10.32382/mf.v17i1.1972