EVALUASI KRIM ANTIOKSIDAN SOLID LIPID MICROPARTICLE EKSTRAK ETANOL DAUN KERSEN (Muntingia calabura)
Abstract
ABSTRAK
Kersen (Muntingia calabura L.) leaves is a plant that contains flavonoids as antioxidants which can be formulated in Solid Lipid Microparticle. The aim of this study is to make Solid Lipid Microparticle cream loaded ethanol extract of kersen leaves preparation and evaluated it’s physical stability. Solid Lipid Microparticle was made of 3% kersen leaves ethanol extract with entrapment efficiency 85.75% formulated in cream preparation with variation of cetyl alcohol concentration namely F1 (2%), F2 (4%), F3 (6%), then tested it’s stability before and after accelerated storage using climatic chamber. The results showed that the three formulas fulfilled the quality of preparation with organoleptic, homogenity, type of cream, viscosity, pH, and spreadability parameters before and after accelerated conditions.
Keywords : Kersen leaves, Muntingia calabura L., physical stability, Solid Lipid Microparticle Cream
Keywords
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Asdar, M. 2015. Formulasi dan Evaluasi Solid Lipid Microparticle Ekstrak Etanol Daun Kersen (Muntingia calabura L.) Sebagai Antioksidan. Sekolah Tinggi Ilmu Farmasi: Makassar.
Chengyu Gu, H.Caibiao, M.Chaolong, F.Qiao, X.Tingkang, dan X.Qiang. 2016. Development and Characterization of Solid Lipid Microparticles Cpntaining Vitamin C for Topical and Cosmetic use. Southeast University : China.
Fatmawaty, A., Nisa M., Riski R. 2015. Teknologi Sediaan Farmasi. Yogyakarta: Deepublish.
Genatrika E., Nurkhikmah I., dan Hapsari I. 2016. Formulasi sediaan krim minyak jintan hitam (Nigella sativa L.) Sebagai antijerawat terhadap bakteri Propionibacterium acnes. Universitas Muhammadiyah: Purwokerto.
Imrawat.i, Mus S., Gani, A.S, dan Bubua I.K. 2017. Antioxidant Activity Of Ethyl Acetate Fraction Of Muntingia calabura L. Leaves. Sekolah Tinggi Ilmu farmasi: Makassar. 2(2): 59-62.
Kuntorini, E.M, Setya F., Maria D.A. 2013. Struktur Anatomi dan UjiAktivitas Antioksidan Ekstrak Metanol Daun Kersen (Muntingia calabura L.). Universitas Lambung Mangkurat: Lampung.
Lachman L., Lieberman H.A., dan Kanig J.L. 1994. Teori dan Praktek Farmasi Industri. UI Press : Jakarta.
Puspitasari, D.A dan Wulandari, L.R. 2017. Aktivitas Antioksidan, Penetapan Kadar Fenolik Total dan Flavanoid Total Ekstrak Daun Kersen (Muntingia calabura L.). Universitas Wahid Hasyim: Semarang. Vo.7, No.2.
Roy, A., Choudhury, A., Verma, A. 2014. Phytosome : A Novel Form For Herbal Drug Dellivery. Journal of Applied Pharmaceutical Research : Columbia.
Sami, F,J., Nur, S., Ramli N., dan B.Sutrisno. 2017. Uji Aktivitas Antioksidan Daun Kersen (Muntingia calabura L.) Dengan Metode DPPH (1,1-difenil-2-pikrilhidrazil) dan FRAP (Ferric Reducing Antioxidan Power). Sekolah Tinggi Ilmu Farmasi: Makassar.
Sari, N. A. 2015. Antioksidan Alternatif Untuk Menangkal Bahaya Radikal Bebas Pada Kulit. Universitas Islam Negeri Ar Raniry: Banda Aceh.
Sayuti K, Yenrina R. 2015. Antioksidan Alami dan Sintetik. Andalas University Press: Padang.
Swastika A., Mufrod, P. 2013. Aktivitas Antioksidan Krim Ekstrak Sari Tomat (Solanum iycopersicum L.). Universitas Gadjah Mada: Yogyakarta.
Voight R. 1994. Buku Pelajaran Teknologi Farmasi. Edisi Ke-5. Diterjemahkan Oleh: Dr Soendi Noerono. Gadjah Mada University Press: Yogyakarta.
DOI: https://doi.org/10.32382/medkes.v15i1.1208
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