PROFIL HEMATOLOGI PASIEN ANAK DENGAN TIFOID SERTA KORELASINYA TERHADAP LAMA RAWAT INAP

Rike Syahniar; Khayrul Fikri; Matahari Arumdini; Rayhana Rayhana

doi:10.32382/medkes.v15i1.1210

PROFIL HEMATOLOGI PASIEN ANAK DENGAN TIFOID SERTA KORELASINYA TERHADAP LAMA RAWAT INAP

Rike Syahniar, Khayrul Fikri, Matahari Arumdini, Rayhana Rayhana

Abstract

ABSTRACT

Leukopenia, thrombocytopenia and anemia are haematological abnormalities that are usually found in typhoid fever patients. This study aims to determine the relationship between platelet counts, leukocyte counts, hematocrit values and haemoglobin in pediatric typhoid patients. This research is a descriptive and analytic study using the parameters of hematology and length of stay in children at the Jakarta Cempaka Putih Islamic Hospital. The data used are secondary data in the form of medical records of patients from January to June 2018 who were diagnosed with typhoid fever. Data analysis using the Kolmogorov Smirnov and Chi-square test. The average age and length of stay of the patients were 9 years and 4.6 days. Bivariate analysis showed no relationship between length of stay with platelet count (p = 1.000), leukocytes (p = 0.969), hematocrit value (p = 1.000) and haemoglobin (p=0.549). There was no significant relationship between overall hematological parameters and length of hospital stay.

Keywords: Length of stay, parameters of hematology, typhoid fever.

Abstrak

Leukopenia, trombositopenia dan anemia merupakan kelainan hematologis yang biasanya ditemukan pada pasien demam tifoid. Penelitian ini bertujuan untuk mengetahui hubungan antara jumlah trombosit, jumlah leukosit, nilai hematokit dan hemoglobin pada pasien tifoid anak. Penelitian ini merupakan deskriptif dan analitik menggunakan variabel parameter hematologi dan lama rawat pada anak di Rumah Sakit Islam Jakarta Cempaka Putih. Data yang digunakan yaitu data sekunder berupa rekam medik pasien periode Januari – Juni 2018 yang di diagnosis demam tifoid. Analisis data menggunakan uji Kolmogorov Smirnov dan Chi-square. Rata-rata usia dan lama rawat inap pasien yaitu 9 tahun dan 4,6 hari. Analisis bivariat menunjukkan tidak terdapat hubungan antara lama rawat dengan jumlah trombosit (p=1.000), leukosit (p=0.969),nilai hematokrit (p=1.000) dan hemoglobin (p=0.549). Tidak terdapat hubungan yang bermakna antara keseluruhan parameter hematologi dengan lama rawat inap

Kata kunci: Demam tifoid, lama rawat, parameter hematologi

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References

Abro AH, Abdou AMS, Gangwani JL, Ustadi AM, Younis NJ, Hussaini HS. 2009. Ischemia modified albumin a potent marker in acute myocardial infarction in normolipidaemic. Pak J Med Sci, 25(2):166-171.

Adiputra IKGT, Somia IKA. 2017. Karakteristik Klinis Pasien Demam Tifoid di RSUP Sanglah Periode Waktu Juli 2013 – Juli 2014. E-Jurnal Medika, 6(11): 98–102.

Ahmedullah H, Khan FY, Maslamani MA, Soub HA, Chacko A, Khattab MA.2018. Epidemiological and Clinical Features of Salmonella Typhi Infection Among Adult Patients in Qatar: A Hospital-based Study. Oman medical Journal, 33(6):468-472

Akhtar S, et al. 2012. Hematological changes in malaria: a comparative study. IOSR-JPBS, 2:15–9.

Ardiaria M. 2019. Epidemiologi, Manifestasi Klinis, dan Penatalaksanaan Demam Tifoid. Journal of Nutrition and Health, 7(2):32-38.

Baek H, Minsu Cho, Kim S, Hwang H, Song M, Yoo S. 2018.Analysis of length of hospital stay using electronic health records: A statistical and data mining approach. PLoS ONE, 13(4):e0195901

Chau TT, Campbell JI, Galindo CM. 2007.Antimicrobial drug resistance of Salmonella enterica serovar Typhi in Asia and molecular mechanism of reduced susceptibility to the fluoroquinolones. Antimicrob Agents Chemother, 51:4315–4323.

Depkes RI. 2013. Sistematika Pedoman Pengendalian Penyakit Demam Tifoid. Jakarta: Direktorat Jendral Pengendalian Penyakit & Penyehatan Lingkungan.

Handayani NPDP, Mutiarasari D. 2017. Karakteristik Usia, Jenis Kelamin, Tingkat Demam, Kadar Hemoglobin, Leukosit dan Trombosit Penderita Demam Tifoid pada Pasien Anak di RSU Antapura Tahun 2013. Medika Tadulako Jurnal Ilmiah Kedokteran, 4(2):30-40.

Farogh, Qayyum, Haleem,Ghaffar. 2009. Haematological abnormalities in malaria. Biomedica, 5(52–5):5.

Ifeanyi OE. 2014. Changes in some haematological parameters in typhoid patients attending University Health Services Department of Michael Okpara University of Agriculture, Nigeria. Int.J.Curr.Microbiol.App.Sci, 3(1): 670-674

Jonga HK, Parry CM , Vaart TW, Kagera LM, Ende SJ, Maude RR, et al. 2018. Activation of coagulation and endothelium with concurrent impairment of anticoagulant mechanisms in patients with typhoid fever. Journal of Infection, 77(1):60-67

Kementerian Kesehatan Republik Indonesia. 2006. Pedoman Pengendalian Demam Tifoid. Jakarta: Kemenkes RI.

Khan M, Coovadia Y, Connolly C, Sturm AW. Risk factors predicting complications in blood culture‐proven typhoid fever in adults. Scand J Infect Dis 2000: 32: 201–205.

Lestari RP, Arguni E. Clinical Profile of Typhoid Fever in Children at Dr Sardjito General Hospital Yogyakarta. Sari Pediatri. 2017;19(3):139-144.

Malik AS. Complications of bacteriologically confirmed typhoid fever in children. J Trop Pediatr 2002: 48: 102–108.

Purba IE, Wandra T, Nugrahini N, Nawawi S, Kandun N. 2016. Program Pengendalian Demam Tifoid di Indonesia: tantangan dan peluang. Media Litbangkes, 26(2):99-108.

Saraswati N, Junaidi AR, Ulfa M. 2012. Karakteristik Tersangka Demam Tifoid Pasien Rawat Inap di Rumah Sakit Muhammadiyah Palembang Periode Tahun 2010. Syifa’MEDIKA. 3(1).

Shrivastava K , Vahikar S, Mishra V. 2015. Hematological profile in typhoid fever. Trop J Path Micro, 1(1):16-20

Umah AK, Wirjatmadi RB. Asupan Protein, Lemak, Karbohidrat dan Lama Hari Rawat Pasien Demam Tifoid di RSUD DR. Moh. Seowandhie Surabaya. Jurnal Widya Medika Surabaya 2014;2(2):99-106.

Widyastuti H. 2018. Evaluasi Sensitifitas dan Spesifitas ELISA dan PBA untuk Deteksi IgM Terhadap Antigen LPS Salmonella Typhi. Jurnal Ilmu Alam dan Lingkungan, 9(18):31–41.

DOI: https://doi.org/10.32382/medkes.v15i1.1210