The Effect of God's Crown Fruit Extract and Cinnamon Extract On Decrease Total Cholesterol Levels In Rats White Male

Sainal Edi Kamal, Zulfiah Zulfiah, Rina Asrina, Herman Herman, Gerfan Patandung, Alfreds Roosevelt, Muh. Farid, Megawati Megawati, Sulfiyana H. Ambo Lau, Muhammad Taufiq Duppa, Syachriyani Syachriyani, Firmansyah Firmansyah, Agust Dwi Djajanti, Rusli Rusli

Abstract


God’s Crown contains chemicals that can cure various diseases including detoxification, anti-bacterial, anti-viral, lowering sugar levels, blood clotting in the body, anti-inflammatory, anti-oxidant, reducing fat deposits and cholesterol content in blood vessel walls. Cinnamon bark can lower blood glucose levels, total cholesterol, and triglyceride levels, and on the other hand can increase HDL levels. The purpose of this study was to determine the effect of giving God’s Crown Fruit Extract (Pheleria macrocarpa (Scheff.) Boerl) and Cinnamon Extract (Cinnamomum burmanii) on the reduction of total cholesterol levels in male white rats (Rattus norvegicus). The research method was Experimental Laboratory which was carried out at the Pharmacology and Phytochemical Laboratory, Faculty of Mathematics and Natural Sciences, Pancasakti University. The method used was propylthiouracil induction and high fat administration by measuring total cholesterol levels in male white rats using a glucometer. 15 male rats used were divided into 5 groups, namely negative control (CMC.Na 1% w/v), God’s Crown Fruit Extract and Cinnamon Extract, God’s Crown Fruit Extract 0.6% w/v, Wood Extract Sweet 1.2% w/v, positive control (Atorvastatin). Observations on the decrease in total cholesterol levels were carried out 1 day after treatment. Based on the results of the analysis using ANOVA with SPSS 25, the percentage reduction in total cholesterol levels showed that the administration of God’s Crown fruit extract and cinnamon extract, God’s Crown fruit extract 0.6% w/v, cinnamon extract 1.2% w/v , and atorvastatin showed the effect of reducing total cholesterol levels in male white rats and the administration of the fruit extract of God’s Crown and cinnamon extract which showed the best effect on reducing total cholesterol levels in male white rats.

Keywords: Cholesterol, cinnamon, god's crown fruit

 


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DOI: https://doi.org/10.32382/uh.v3i1.2518

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