ANALISIS FAKTOR YANG BERPENGARUH TERHADAP KEJADIAN INTERAKSI OBAT PADA PASIEN HIPERTENSI DI RUMAH SAKIT UMUM X KOTA MAKASSAR

Raimundus Chalik; Djuniasti Karim; Sisilia Teresia Rosmala Dewi; Hidayati Hidayati

doi:10.32382/mf.v17i1.2018

ANALISIS FAKTOR YANG BERPENGARUH TERHADAP KEJADIAN INTERAKSI OBAT PADA PASIEN HIPERTENSI DI RUMAH SAKIT UMUM X KOTA MAKASSAR

Raimundus Chalik, Djuniasti Karim, Sisilia Teresia Rosmala Dewi, Hidayati Hidayati

Abstract

Analysis Of Factors That Affect The Incidence Of Drug Interactions In Hypertensive Patients At A Regional General Hospitals In Makassar City

Drug interactions are directly related to factors such as polypharmacy. Meanwhile, patients with hypertension are at high risk for potential drug interactions due to the large number and types of drugs consumed. Therefore, this research aims to determine the potential for drug interactions in hypertensive patients at one of the Makassar City General Hospitals. It also analyzed the factors with the most significant effect on the potential for drug interactions. Furthermore, this is a descriptive-analytic research with a cross-sectional approach. The sample were determined using a consecutive sampling technique and the research was conducted between March-June 2020. In addition, the potential drug interactions were identified using Micromedex 2.0 software and Handbook of Drug Interaction Fact. Analysis of the factors with the most influence on potential for drug interactions was performed using multiple logistic regression statistical tests. The results showed that the number of drugs prescribed had a significant influence on the potential for drug interactions with p = 0.023, OR = 11.676 (9% CI 1.401-97.322). Based on the results, the number of drugs prescribed is the most influential factor in the potential for drug interactions.

Keywords : drug interactions, hypertension, influencing factors, Regional General Hospital

Interaksi obat secara langsung berhubungan dengan faktor seperti polifarmasi. Pasien dengan hipertensi beresiko tinggi terhadap potensi kejadian interaksi obat-obat disebabkan karena banyaknya jumlah dan jenis obat yang mereka terima. Tujuan dari penelitian adalah untuk menentukan potensi interaksi obat pada pasien hipertensi di RSU X Kota Makassar dan menganalisis faktor yang paling berpengaruh terhadap potensi interaksi obat. Penelitian merupakan deskriptik analitik dengan pendekatan cross-sectional study. Penentuan sampel menggunaan teknik consequtive sampling. Penelitian ini dilaksanakan di RSU X Kota Makassar selama periode Maret-Juni 2020. Identifikasi potensi interaksi obat dilakukan dengan menggunakan Micromedex 2,0 software dan Handbook of Drug Interaction Fact. Analisis faktor yang paling berpengaruh terhadap potensi interaksi obat dilakukan dengan uji statistik regresi logistik ganda. Hasil penelitian ini menemukan faktor jumlah obat yang diresepkan memiliki pengaruh yang signifikan terhadap potensi interaksi obat dengan p=0,023,OR=11,676 (IK 9%1,401-97,322). Hasil penelitian menyimpulkan jumlah obat yang diresepkan merupakan faktor yang paling berpengaruh terhadap potensi interaksi obat.

Kata kunci : interaksi obat, hipertensi, faktor yang berpengaruh

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DOI: https://doi.org/10.32382/mf.v17i1.2018